Control of bacterial persister cells by Trp/Arg-containing antimicrobial peptides.

@article{Chen2011ControlOB,
  title={Control of bacterial persister cells by Trp/Arg-containing antimicrobial peptides.},
  author={Xi Chen and Mi Zhang and Chun Hui Zhou and Neville R. Kallenbach and Dacheng Ren},
  journal={Applied and environmental microbiology},
  year={2011},
  volume={77 14},
  pages={
          4878-85
        }
}
Persister cells are dormant phenotypic variants inherent in a bacterial population. They play important roles in chronic infections and present great challenges to therapy due to extremely enhanced tolerance to antibiotics compared to that of normal cells of the same genotype. In this study, we report that cationic membrane-penetrating peptides containing various numbers of arginine and tryptophan repeats are effective in killing persister cells of Escherichia coli HM22, a hyper-persister… CONTINUE READING
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