Control of axonal caliber by neurofilament transport

  title={Control of axonal caliber by neurofilament transport},
  author={Paul Ned Hoffman and John Wesley Griffin and Donald L. Price},
  journal={The Journal of Cell Biology},
  pages={705 - 714}
The role of neurofilaments, the intermediate filaments of nerve cells, has been conjectural. Previous morphological studies have suggested a close relationship between neurofilament content and axonal caliber. In this study, the regenerating neuron was used as a model system for testing the hypotheses that neurofilaments are intrinsic determinants of axonal caliber, and that neurofilament content is controlled by the axonal transport of neurofilaments. This system was chosen because previous… CONTINUE READING