Control of appetite, blood glucose, and blood pressure during melanocortin-4 receptor activation in normoglycemic and diabetic NPY-deficient mice.

@article{Silva2018ControlOA,
  title={Control of appetite, blood glucose, and blood pressure during melanocortin-4 receptor activation in normoglycemic and diabetic NPY-deficient mice.},
  author={Alexandre A. da Silva and John Nathan Freeman and John E. Simon Hall and Jussara M do Carmo},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={2018},
  volume={314 4},
  pages={R533-R539}
}
Although central melanocortin 4 receptor (MC4R) blockade abolishes the central nervous system (CNS)-mediated anorexogenic, antidiabetic, and cardiovascular actions of leptin, chronic MC4R stimulation fails to completely mimic the effects of leptin. Because neuropeptide Y (NPY) and MC4R exert opposite effects on cardiovascular and metabolic functions, we… CONTINUE READING