Control of apoptosis in influenza virus-infected cells by up-regulation of Akt and p53 signaling

@article{Zhirnov2007ControlOA,
  title={Control of apoptosis in influenza virus-infected cells by up-regulation of Akt and p53 signaling},
  author={Oleg P. Zhirnov and H -D Klenk},
  journal={Apoptosis},
  year={2007},
  volume={12},
  pages={1419-1432}
}
PI3k-Akt and p53 pathways are known to play anti- and pro-apoptotic roles in cell death, respectively. Whether these pathways are recruited in influenza virus infection in highly productive monkey (CV-1) and canine (MDCK) kidney cells was studied here. Phosphorylation of Akt (Akt-pho) was found to occur only early after infection (5–9 h.p.i). Nuclear accumulation and phosphorylation of p53 (p53-pho), and expression of its natural target p21/waf showed low constitutive levels at this period… CONTINUE READING

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