Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy

  title={Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy},
  author={Peter E. Czabotar and Guillaume Lessene and Andreas Strasser and Jerry M. Adams},
  journal={Nature Reviews Molecular Cell Biology},
The BCL-2 protein family determines the commitment of cells to apoptosis, an ancient cell suicide programme that is essential for development, tissue homeostasis and immunity. Too little apoptosis can promote cancer and autoimmune diseases; too much apoptosis can augment ischaemic conditions and drive neurodegeneration. We discuss the biochemical, structural and genetic studies that have clarified how the interplay between members of the BCL-2 family on mitochondria sets the apoptotic threshold… CONTINUE READING
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