Control of amyloid assembly by autoregulation.

  title={Control of amyloid assembly by autoregulation.},
  author={Michael Landreh and Jan J Johansson and Anna Rising and Jenny Presto and Hans J{\"o}rnvall},
  journal={The Biochemical journal},
  volume={447 2},
The assembly of proteins into amyloid fibrils can be an element of both protein aggregation diseases and a functional unit in healthy biological pathways. In both cases, it must be kept under tight control to prevent undesired aggregation. In normophysiology, proteins can self-chaperone amyloidogenic segments by restricting their conformational flexibility in an overall stabilizing protein fold. However, some aggregation-prone segments cannot be controlled in this manner and require additional… CONTINUE READING
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