Control of amyloid assembly by autoregulation.

@article{Landreh2012ControlOA,
  title={Control of amyloid assembly by autoregulation.},
  author={Michael Landreh and Jan J Johansson and Anna Rising and Jenny Presto and Hans J{\"o}rnvall},
  journal={The Biochemical journal},
  year={2012},
  volume={447 2},
  pages={185-92}
}
The assembly of proteins into amyloid fibrils can be an element of both protein aggregation diseases and a functional unit in healthy biological pathways. In both cases, it must be kept under tight control to prevent undesired aggregation. In normophysiology, proteins can self-chaperone amyloidogenic segments by restricting their conformational flexibility in an overall stabilizing protein fold. However, some aggregation-prone segments cannot be controlled in this manner and require additional… CONTINUE READING
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