Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation


T lymphocytes must regulate nutrient uptake to meet the metabolic demands of an immune response. Here we show that the intracellular supply of large neutral amino acids (LNAAs) in T cells was regulated by pathogens and the T cell antigen receptor (TCR). T cells responded to antigen by upregulating expression of many amino-acid transporters, but a single… (More)
DOI: 10.1038/ni.2556


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