Control of aldosterone secretion: a model for convergence in cellular signaling pathways.

@article{Spt2004ControlOA,
  title={Control of aldosterone secretion: a model for convergence in cellular signaling pathways.},
  author={Andr{\'a}s Sp{\"a}t and L{\'a}szl{\'o} Hunyady},
  journal={Physiological reviews},
  year={2004},
  volume={84 2},
  pages={
          489-539
        }
}
Aldosterone secretion by glomerulosa cells is stimulated by angiotensin II (ANG II), extracellular K(+), corticotrophin, and several paracrine factors. Electrophysiological, fluorimetric, and molecular biological techniques have significantly clarified the molecular action of these stimuli. The steroidogenic effect of corticotrophin is mediated by adenylyl cyclase, whereas potassium activates voltage-operated Ca(2+) channels. ANG II, bound to AT(1) receptors, acts through the inositol 1,4,5… 

Signaling Interactions in the Adrenal Cortex

Cross-actions of parallel signal transducing pathways are not mere intracellular curiosities but rather substantial phenomena, which fine-tune the biological response.

Calcium-dependent mitochondrial cAMP production enhances aldosterone secretion

Minireview: aldosterone biosynthesis: electrically gated for our protection.

Aldosterone produced by adrenal zona glomerulosa (ZG) cells plays an important role in maintaining salt/water balance and, hence, blood pressure homeostasis. However, when dysregulated, aldosterone

Regulation of aldosterone production from zona glomerulosa cells by ANG II and cAMP: evidence for PKA-independent activation of CaMK by cAMP.

This work found that Ca(2+)/calmodulin-dependent protein kinases (CaMKs) play a predominant role in the regulation of aldosterone production stimulated by ANG II, ACTH, and cAMP, and provides evidence that cAMP effects in ZG cells do not involve Ca( 2+) or MAPK signaling.

Potassium channels in adrenocortical cells

Effect of aldosterone on BK channel expression in mammalian cortical collecting duct.

It is suggested that aldosterone does not contribute to the regulation of BK channel expression/activity in response to dietary K(+) loading, and the flow-stimulated increase in J(K) was similar in both groups.

D4 dopamine receptor enhances angiotensin II-stimulated aldosterone secretion through PKC-epsilon and calcium signaling.

D4R augmented aldosterone synthesis/secretion induced by AII through enhancing PKC-epsilon phosphorylation and [Ca(2+)](i) elevation, and inhibitory peptide attenuated AII-stimulated ald testosterone secretion, CYP11B2 mRNA expression, and elevation of intracellular IP(3) and[Ca( 2+](i).

Mitochondrial matrix calcium is an activating signal for hormone secretion.

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The present discussion will focus on the role of calcium (Ca2+) in the acute (hours vs. days) regulation of aldosterone secretion by Ang II.

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