Control of aldosterone production by angiotensin II is mediated by two guanine nucleotide regulatory proteins.

@article{Hausdorff1987ControlOA,
  title={Control of aldosterone production by angiotensin II is mediated by two guanine nucleotide regulatory proteins.},
  author={William P. Hausdorff and Ronald D. Sekura and Guillermo Romero Aguilera and KevinJ. Catt},
  journal={Endocrinology},
  year={1987},
  volume={120 4},
  pages={
          1668-78
        }
}
The involvement of guanine nucleotide regulatory proteins in the steroidogenic response of the adrenal glomerulosa to angiotensin II (AII) was investigated by analyzing the effects of Bordetella pertussis toxin (PT) on several aspects of AII action. These included receptor binding, stimulation of aldosterone production and GTPase activity, inhibition of cAMP production, and attenuation of the aldosterone response at high angiotensin concentrations. Pretreatment of glomerulosa cells with PT… CONTINUE READING
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