Control of adipose tissue expandability in response to high fat diet by the insulin-like growth factor-binding protein-4.

@article{Gealekman2014ControlOA,
  title={Control of adipose tissue expandability in response to high fat diet by the insulin-like growth factor-binding protein-4.},
  author={Olga Gealekman and Kunal Gurav and My Chouinard and Juerg R. Straubhaar and Michael J. Thompson and Samir Malkani and Celia Hartigan and Silvia Corvera},
  journal={The Journal of biological chemistry},
  year={2014},
  volume={289 26},
  pages={
          18327-38
        }
}
Adipose tissue expansion requires growth and proliferation of adipocytes and the concomitant expansion of their stromovascular network. We have used an ex vivo angiogenesis assay to study the mechanisms involved in adipose tissue expansion. In this assay, adipose tissue fragments placed under pro-angiogenic conditions form sprouts composed of endothelial, perivascular, and other proliferative cells. We find that sprouting was directly stimulated by insulin and was enhanced by prior treatment of… CONTINUE READING
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