Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt.

  title={Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt.},
  author={Jernej Murn and Kathi Zarnack and Yawei J. Yang and Omer Durak and Elisabeth A. Murphy and Sihem Cheloufi and Dilenny M. Gonzalez and Marianna Teplova and Toma{\vz} Curk and Johannes Zuber and Dinshaw J. Patel and Ule Jernej and Nicholas M. Luscombe and Li-Huei Tsai and Christopher A. Walsh and Yang Shi},
  journal={Genes & development},
  volume={29 5},
Cellular morphology is an essential determinant of cellular function in all kingdoms of life, yet little is known about how cell shape is controlled. Here we describe a molecular program that controls the early morphology of neurons through a metazoan-specific zinc finger protein, Unkempt. Depletion of Unkempt in mouse embryos disrupts the shape of migrating neurons, while ectopic expression confers neuronal-like morphology to cells of different nonneuronal lineages. We found that Unkempt is a… CONTINUE READING
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