Control of Viremia and Prevention of AIDS following Immunotherapy of SIV-Infected Macaques with Peptide-Pulsed Blood

@article{Rose2008ControlOV,
  title={Control of Viremia and Prevention of AIDS following Immunotherapy of SIV-Infected Macaques with Peptide-Pulsed Blood},
  author={R. De Rose and C. Fernandez and M. Z. Smith and C. Batten and S. Alc{\^a}ntara and V. Peut and E. Rollman and L. Loh and R. Mason and K. Wilson and M. Law and A. Handley and S. Kent},
  journal={PLoS Pathogens},
  year={2008},
  volume={4}
}
Effective immunotherapies for HIV are needed. Drug therapies are life-long with significant toxicities. Dendritic-cell based immunotherapy approaches are promising but impractical for widespread use. A simple immunotherapy, reinfusing fresh autologous blood cells exposed to overlapping SIV peptides for 1 hour ex vivo, was assessed for the control of SIVmac251 replication in 36 pigtail macaques. An initial set of four immunizations was administered under antiretroviral cover and a booster set of… Expand
Substantial envelope-specific CD8 T-cell immunity fails to control SIV disease.
Inactivated Simian Immunodeficiency Virus-Pulsed Autologous Fresh Blood Cells as an Immunotherapy Strategy
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