Control of Vertebrate Skeletal Mineralization by Polyphosphates

@article{Omelon2009ControlOV,
  title={Control of Vertebrate Skeletal Mineralization by Polyphosphates},
  author={Sidney Omelon and John Georgiou and Zachary J. Henneman and Lisa M. Wise and Balram Sukhu and Tanya Hunt and Chrystia Wynnyckyj and Douglas Holmyard and Ryszard Bielecki and Marc D. Grynpas},
  journal={PLoS ONE},
  year={2009},
  volume={4},
  pages={1 - 324}
}
BACKGROUND Skeletons are formed in a wide variety of shapes, sizes, and compositions of organic and mineral components. Many invertebrate skeletons are constructed from carbonate or silicate minerals, whereas vertebrate skeletons are instead composed of a calcium phosphate mineral known as apatite. No one yet knows why the dynamic vertebrate skeleton, which is continually rebuilt, repaired, and resorbed during growth and normal remodeling, is composed of apatite. Nor is the control of bone and… CONTINUE READING

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