Control of Treg and TH17 cell differentiation by the aryl hydrocarbon receptor

  title={Control of Treg and TH17 cell differentiation by the aryl hydrocarbon receptor},
  author={F. Quintana and A. Basso and A. Iglesias and T. Korn and M. Farez and E. Bettelli and M. C{\'a}ccamo and M. Oukka and H. Weiner},
  • F. Quintana, A. Basso, +6 authors H. Weiner
  • Published 2008
  • Biology, Medicine
  • Nature
  • Regulatory T cells (Treg) expressing the transcription factor Foxp3 control the autoreactive components of the immune system. The development of Treg cells is reciprocally related to that of pro-inflammatory T cells producing interleukin-17 (TH17). Although Treg cell dysfunction and/or TH17 cell dysregulation are thought to contribute to the development of autoimmune disorders, little is known about the physiological pathways that control the generation of these cell lineages. Here we report… CONTINUE READING
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