Control of Treg and TH17 cell differentiation by the aryl hydrocarbon receptor
@article{Quintana2008ControlOT, title={Control of Treg and TH17 cell differentiation by the aryl hydrocarbon receptor}, author={F. Quintana and A. Basso and A. Iglesias and T. Korn and M. Farez and E. Bettelli and M. C{\'a}ccamo and M. Oukka and H. Weiner}, journal={Nature}, year={2008}, volume={453}, pages={65-71} }
Regulatory T cells (Treg) expressing the transcription factor Foxp3 control the autoreactive components of the immune system. The development of Treg cells is reciprocally related to that of pro-inflammatory T cells producing interleukin-17 (TH17). Although Treg cell dysfunction and/or TH17 cell dysregulation are thought to contribute to the development of autoimmune disorders, little is known about the physiological pathways that control the generation of these cell lineages. Here we report… CONTINUE READING
882 Citations
Activation of the aryl hydrocarbon receptor induces human type 1 regulatory T cell–like and Foxp3+ regulatory T cells
- Biology, Medicine
- Nature Immunology
- 2010
- 305
T cells: Tuning T cells through the aryl hydrocarbon receptor
- Chemistry
- Nature Reviews Immunology
- 2008
- 1
The roles of aryl hydrocarbon receptor in immune responses.
- Medicine, Biology
- International immunology
- 2013
- 129
- PDF
Generation of IL-8 and IL-9 Producing CD4+ T Cells Is Affected by Th17 Polarizing Conditions and AHR Ligands
- Biology, Medicine
- Mediators of inflammation
- 2014
- 18
- PDF
The Aryl hydrocarbon Receptor (AhR) interacts with c-Maf to promote the differentiation of IL-27-induced regulatory type 1 (TR1) cells
- Biology, Medicine
- Nature Immunology
- 2010
- 237
Suppression of experimental autoimmune uveoretinitis by inducing differentiation of regulatory T cells via activation of aryl hydrocarbon receptor.
- Biology, Medicine
- Investigative ophthalmology & visual science
- 2010
- 82
- PDF
Control of the differentiation of regulatory T cells and TH17 cells by the DNA-binding inhibitor Id3
- Biology, Medicine
- Nature Immunology
- 2011
- 138
References
SHOWING 1-10 OF 49 REFERENCES
Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
- Chemistry, Medicine
- Nature
- 2006
- 6,270
IL-21 initiates an alternative pathway to induce proinflammatory TH17 cells
- Chemistry, Medicine
- Nature
- 2007
- 1,780
The Orphan Nuclear Receptor RORγt Directs the Differentiation Program of Proinflammatory IL-17+ T Helper Cells
- Biology
- Cell
- 2006
- 2,685
Reciprocal TH17 and Regulatory T Cell Differentiation Mediated by Retinoic Acid
- Biology, Medicine
- Science
- 2007
- 1,786
Foxp3 transcription-factor-dependent and -independent regulation of the regulatory T cell transcriptional signature.
- Biology, Medicine
- Immunity
- 2007
- 561
- PDF
Control of Regulatory T Cell Development by the Transcription Factor Foxp3
- Biology, Medicine
- Science
- 2003
- 7,727
- PDF
TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells.
- Biology, Medicine
- Immunity
- 2006
- 3,600
IL-2 Receptor β-Dependent STAT5 Activation Is Required for the Development of Foxp3+ Regulatory T Cells1
- Biology, Medicine
- The Journal of Immunology
- 2007
- 737
- PDF
Epidermal RANKL controls regulatory T-cell numbers via activation of dendritic cells
- Biology, Medicine
- Nature Medicine
- 2006
- 365