Control of Treg and TH17 cell differentiation by the aryl hydrocarbon receptor

@article{Quintana2008ControlOT,
  title={Control of Treg and TH17 cell differentiation by the aryl hydrocarbon receptor},
  author={F. Quintana and A. Basso and A. Iglesias and T. Korn and M. Farez and E. Bettelli and M. C{\'a}ccamo and M. Oukka and H. Weiner},
  journal={Nature},
  year={2008},
  volume={453},
  pages={65-71}
}
  • F. Quintana, A. Basso, +6 authors H. Weiner
  • Published 2008
  • Biology, Medicine
  • Nature
    • Regulatory T cells (Treg) expressing the transcription factor Foxp3 control the autoreactive components of the immune system. The development of Treg cells is reciprocally related to that of pro-inflammatory T cells producing interleukin-17 (TH17). Although Treg cell dysfunction and/or TH17 cell dysregulation are thought to contribute to the development of autoimmune disorders, little is known about the physiological pathways that control the generation of these cell lineages. Here we report… CONTINUE READING
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    References

    SHOWING 1-10 OF 49 REFERENCES
    Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
    • 6,270
    IL-21 initiates an alternative pathway to induce proinflammatory TH17 cells
    • 1,780
    The Orphan Nuclear Receptor RORγt Directs the Differentiation Program of Proinflammatory IL-17+ T Helper Cells
    • 2,685
    Reciprocal TH17 and Regulatory T Cell Differentiation Mediated by Retinoic Acid
    • 1,786
    TH-17 cells in the circle of immunity and autoimmunity
    • 1,476
    Foxp3 transcription-factor-dependent and -independent regulation of the regulatory T cell transcriptional signature.
    • 561
    • PDF
    Control of Regulatory T Cell Development by the Transcription Factor Foxp3
    • 7,727
    • PDF
    TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells.
    • 3,600
    IL-2 Receptor β-Dependent STAT5 Activation Is Required for the Development of Foxp3+ Regulatory T Cells1
    • 737
    • PDF
    Epidermal RANKL controls regulatory T-cell numbers via activation of dendritic cells
    • 365