Control of Translation and miRNA-Dependent Repression by a Novel Poly(A) Binding Protein, hnRNP-Q

@inproceedings{Svitkin2013ControlOT,
  title={Control of Translation and miRNA-Dependent Repression by a Novel Poly(A) Binding Protein, hnRNP-Q},
  author={Yuri V. Svitkin and Akiko Yanagiya and Alexey E. Karetnikov and Tommy Alain and Marc R Fabian and Arkady Khoutorsky and Sandra Perreault and Ivan Topisirovic and Nahum Sonenberg},
  booktitle={PLoS biology},
  year={2013}
}
Translation control often operates via remodeling of messenger ribonucleoprotein particles. The poly(A) binding protein (PABP) simultaneously interacts with the 3' poly(A) tail of the mRNA and the eukaryotic translation initiation factor 4G (eIF4G) to stimulate translation. PABP also promotes miRNA-dependent deadenylation and translational repression of target mRNAs. We demonstrate that isoform 2 of the mouse heterogeneous nuclear protein Q (hnRNP-Q2/SYNCRIP) binds poly(A) by default when PABP… CONTINUE READING
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