Control of T helper 2 responses by transcription factor IRF4-dependent dendritic cells.

@article{Gao2013ControlOT,
  title={Control of T helper 2 responses by transcription factor IRF4-dependent dendritic cells.},
  author={Yan Gao and Simone A Nish and Ruoyi Jiang and Lin Hou and Paula Licona-Limon and Jason S. Weinstein and Hongyu Zhao and Ruslan Medzhitov},
  journal={Immunity},
  year={2013},
  volume={39 4},
  pages={722-32}
}
CD4⁺ T cell differentiation is regulated by specialized antigen-presenting cells. Dendritic cells (DCs) produce cytokines that promote naive CD4⁺ T cell differentiation into T helper 1 (Th1), Th17, and inducible T regulatory (iTreg) cells. However, the initiation of Th2 cell responses remains poorly understood, although it is likely that more than one mechanism might be involved. Here we have defined a specific DC subset that is involved in Th2 cell differentiation in vivo in response to a… CONTINUE READING
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