Control of T cell viability.

  title={Control of T cell viability.},
  author={Philippa Marrack and John W. Kappler},
  journal={Annual review of immunology},
The factors affecting T cell viability vary depending on the type and status of the T cell involved. Naive T cells die via a Bcl-2/Bim dependent route. Their deaths are prevented in animals by IL-7 and contact with MHC. Activated T cells die in many different ways. Among these is a pathway involving signals that come from outside the T cell and affect it via surface receptors such as Fas. Activated T cells also die through a pathway driven by signals generated within the T cell itself, a cell… CONTINUE READING

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