Control of Swe1p degradation by the morphogenesis checkpoint.

@article{Sia1998ControlOS,
  title={Control of Swe1p degradation by the morphogenesis checkpoint.},
  author={Rey A. L. Sia and Elaine S.G. Bardes and Daniel J. Lew},
  journal={The EMBO journal},
  year={1998},
  volume={17 22},
  pages={
          6678-88
        }
}
In the budding yeast Saccharomyces cerevisiae, a cell cycle checkpoint coordinates mitosis with bud formation. Perturbations that transiently depolarize the actin cytoskeleton cause delays in bud formation, and a 'morphogenesis checkpoint' detects the actin perturbation and imposes a G2 delay through inhibition of the cyclin-dependent kinase, Cdc28p. The tyrosine kinase Swe1p, homologous to wee1 in fission yeast, is required for the checkpoint-mediated G2 delay. In this report, we show that… CONTINUE READING

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