Control of Stress-Dependent Cardiac Growth and Gene Expression by a MicroRNA

@article{Rooij2007ControlOS,
  title={Control of Stress-Dependent Cardiac Growth and Gene Expression by a MicroRNA},
  author={E. van Rooij and L. Sutherland and X. Qi and J. Richardson and J. Hill and E. Olson},
  journal={Science},
  year={2007},
  volume={316},
  pages={575 - 579}
}
  • E. van Rooij, L. Sutherland, +3 authors E. Olson
  • Published 2007
  • Medicine, Biology
  • Science
  • The heart responds to diverse forms of stress by hypertrophic growth accompanied by fibrosis and eventual diminution of contractility, which results from down-regulation of α–myosin heavy chain (αMHC) and up-regulation of βMHC, the primary contractile proteins of the heart. We found that a cardiac-specific microRNA (miR-208) encoded by an intron of the αMHC gene is required for cardiomyocyte hypertrophy, fibrosis, and expression of βMHC in response to stress and hypothyroidism. Thus, the αMHC… CONTINUE READING

    Paper Mentions

    INTERVENTIONAL CLINICAL TRIAL
    The purpose of this study is to collect data to help researchers identify factors, such as certain proteins or genetic codes, that are secreted from muscle that are associated with the… Expand
    ConditionsDisorder of Lipid Storage and Metabolism, Lipid Metabolism Disorders, Metabolic Disorder, (+1 more)
    InterventionBehavioral
    MicroRNA-208a is a regulator of cardiac hypertrophy and conduction in mice.
    • 709
    • Highly Influenced
    • PDF
    miR-23a functions downstream of NFATc3 to regulate cardiac hypertrophy
    • 308
    • PDF

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 38 REFERENCES
    MicroRNAs Genomics, Biogenesis, Mechanism, and Function
    • 28,178
    • PDF