Control of Stress-Dependent Cardiac Growth and Gene Expression by a MicroRNA

  title={Control of Stress-Dependent Cardiac Growth and Gene Expression by a MicroRNA},
  author={E. van Rooij and L. Sutherland and X. Qi and J. Richardson and J. Hill and E. Olson},
  pages={575 - 579}
  • E. van Rooij, L. Sutherland, +3 authors E. Olson
  • Published 2007
  • Medicine, Biology
  • Science
  • The heart responds to diverse forms of stress by hypertrophic growth accompanied by fibrosis and eventual diminution of contractility, which results from down-regulation of α–myosin heavy chain (αMHC) and up-regulation of βMHC, the primary contractile proteins of the heart. We found that a cardiac-specific microRNA (miR-208) encoded by an intron of the αMHC gene is required for cardiomyocyte hypertrophy, fibrosis, and expression of βMHC in response to stress and hypothyroidism. Thus, the αMHC… CONTINUE READING

    Paper Mentions

    The purpose of this study is to collect data to help researchers identify factors, such as certain proteins or genetic codes, that are secreted from muscle that are associated with the… Expand
    ConditionsDisorder of Lipid Storage and Metabolism, Lipid Metabolism Disorders, Metabolic Disorder, (+1 more)
    MicroRNA-208a is a regulator of cardiac hypertrophy and conduction in mice.
    • 713
    • Highly Influenced
    • PDF
    MicroRNAs in Stress Signaling and Human Disease
    • 1,270
    • PDF
    microRNA-133a regulates cardiomyocyte proliferation and suppresses smooth muscle gene expression in the heart.
    • 672
    • PDF
    Pervasive roles of microRNAs in cardiovascular biology
    • 988


    Publications referenced by this paper.
    MicroRNAs Genomics, Biogenesis, Mechanism, and Function
    • 28,281
    • PDF
    Oncomirs — microRNAs with a role in cancer
    • 6,235
    • PDF
    Combinatorial microRNA target predictions
    • 4,339
    • PDF