Control of Sexual Differentiation and Behavior by the doublesex gene in Drosophila melanogaster

  title={Control of Sexual Differentiation and Behavior by the doublesex gene in Drosophila melanogaster},
  author={Elizabeth J. Rideout and Anthony J. Dornan and Megan C. Neville and Suzanne Eadie and Stephen F Goodwin},
  booktitle={Nature Neuroscience},
Doublesex proteins, which are part of the structurally and functionally conserved Dmrt gene family, are important for sex determination throughout the animal kingdom. We inserted Gal4 into the doublesex (dsx) locus of Drosophila melanogaster, allowing us to visualize and manipulate cells expressing dsx in various tissues. In the nervous system, we detected differences between the sexes in dsx-positive neuronal numbers, axonal projections and synaptic density. We found that dsx was required for… CONTINUE READING
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