Control of Regulatory T Cell Development by the Transcription Factor Foxp3

@article{Hori2003ControlOR,
  title={Control of Regulatory T Cell Development by the Transcription Factor Foxp3},
  author={Shohei Hori and Takashi Nomura and Shimon Sakaguchi},
  journal={Science},
  year={2003},
  volume={299},
  pages={1057 - 1061}
}
Regulatory T cells engage in the maintenance of immunological self-tolerance by actively suppressing self-reactive lymphocytes. Little is known, however, about the molecular mechanism of their development. Here we show that Foxp3, which encodes a transcription factor that is genetically defective in an autoimmune and inflammatory syndrome in humans and mice, is specifically expressed in naturally arising CD4+ regulatory T cells. Furthermore, retroviral gene transfer of Foxp3 converts naïve T… 

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Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo

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FoxP3 and Regulatory T Cells

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