Control of Pseudomonas aeruginosa in the lung requires the recognition of either lipopolysaccharide or flagellin.

@article{Ramphal2008ControlOP,
  title={Control of Pseudomonas aeruginosa in the lung requires the recognition of either lipopolysaccharide or flagellin.},
  author={Reuben Ramphal and Viviane Balloy and Jeevan Jyot and Amrisha Verma and Mustapha Si-Tahar and Michel Chignard},
  journal={Journal of immunology},
  year={2008},
  volume={181 1},
  pages={586-92}
}
Acute lung infection due to Pseudomonas aeruginosa is an increasingly serious problem that results in high mortality especially in the compromised host. In this study, we set out to ascertain what components of the TLR system are most important for innate immunity to this microorganism. We previously demonstrated that TLR2,4-/- mice were not hypersusceptible to infection by a wild-type P. aeruginosa strain. However, we now find that mice lacking both TLR2 and TLR4 (TLR2,4-/- mice) are… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 63 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 43 references

A high-throughput: homogeneous, bioluminescent assay for Pseudomonas aeruginosa gyrase inhibitors and other DNA damaging agents

  • D. T. Moir, T. Opperman, M. Di, H. P. Schweizer, T. L. Bowlin
  • J. Biomolec. Scr
  • 2007

Similar Papers

Loading similar papers…