Control of Peripheral Nerve Myelination by the ß-Secretase BACE1

@article{Willem2006ControlOP,
  title={Control of Peripheral Nerve Myelination by the {\ss}-Secretase BACE1},
  author={M. Willem and A. Garratt and Bo{\vz}idar Novak and M. Citron and S. Kaufmann and Andrea Rittger and B. Destrooper and P. Saftig and C. Birchmeier and C. Haass},
  journal={Science},
  year={2006},
  volume={314},
  pages={664 - 666}
}
Although BACE1 (beta-site amyloid precursor protein–cleaving enzyme 1) is essential for the generation of amyloid-b peptide in Alzheimer's disease, its physiological function is unclear. We found that very high levels of BACE1 were expressed at time points when peripheral nerves become myelinated. Deficiency of BACE1 resulted in the accumulation of unprocessed neuregulin 1 (NRG1), an axonally expressed factor required for glial cell development and myelination. BACE1–/– mice displayed… Expand
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