Control of Neuronal Ryanodine Receptor-Mediated Calcium Signaling by Calsenilin

  title={Control of Neuronal Ryanodine Receptor-Mediated Calcium Signaling by Calsenilin},
  author={Michael A Grillo and Stephanie L. Grillo and Bryan C Gerdes and Jacob G Kraus and Peter Koulen},
  journal={Molecular Neurobiology},
Calsenilin is a calcium ion (Ca2+)-binding protein involved in regulating the intracellular concentration of Ca2+, a second messenger that controls multiple cellular signaling pathways. The ryanodine receptor (RyR) amplifies Ca2+ signals entering the cytoplasm by releasing Ca2+ from endoplasmic reticulum (ER) stores, a process termed calcium-induced calcium release (CICR). Here, we describe a novel mechanism, in which calsenilin controls the activity of neuronal RyRs. We show calsenilin co… CONTINUE READING


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