Control of Mitochondrial Morphology Through Differential Interactions of Mitochondrial Fusion and Fission Proteins

@inproceedings{Huang2011ControlOM,
  title={Control of Mitochondrial Morphology Through Differential Interactions of Mitochondrial Fusion and Fission Proteins},
  author={Pinwei Huang and Chad Galloway and Yisang Yoon},
  booktitle={PloS one},
  year={2011}
}
Mitochondria in mammals are organized into tubular networks that undergo frequent shape change. Mitochondrial fission and fusion are the main components mediating the mitochondrial shape change. Perturbation of the fission/fusion balance is associated with many disease conditions. However, underlying mechanisms of the fission/fusion balance are not well understood. Mitochondrial fission in mammals requires the dynamin-like protein DLP1/Drp1 that is recruited to the mitochondrial surface… CONTINUE READING

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