Control of Low-Density Lipoprotein Concentration in the Arterial Wall by Proportional Drug-Encapsulated Nanoparticles

@article{Rowhanimanesh2012ControlOL,
  title={Control of Low-Density Lipoprotein Concentration in the Arterial Wall by Proportional Drug-Encapsulated Nanoparticles},
  author={Alireza Rowhanimanesh and Mohammad Reza Akbarzadeh-T},
  journal={IEEE Transactions on NanoBioscience},
  year={2012},
  volume={11},
  pages={394-401}
}
Atherosclerosis, or hardening of the arteries, is one of the major causes of death in humans. High accumulation of Low-Density Lipoprotein (LDL) macromolecules within the arterial wall plays a critical role in initiation and development of atherosclerotic plaques. This paper proposes a proportional drug-encapsulated nanoparticle (PDENP) that utilizes a simple piecewise-proportional controller to realize swarm feedback control of LDL concentration in the interior of the arterial wall. In… CONTINUE READING

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