Control of Lactate Production by Membrane Adenosine Triphosphatase Activity in Human Erythrocytes
@article{Whittam1964ControlOL, title={Control of Lactate Production by Membrane Adenosine Triphosphatase Activity in Human Erythrocytes}, author={R. Whittam and M E Ager and James S. Wiley}, journal={Nature}, year={1964}, volume={202}, pages={1111-1112} }
IT is generally believed from Schatzmann's1 work that lactate production in human erythrocytes is unaffected by ouabain and other cardiac glycosides which inhibit the active transport of sodium and potassium. The absence of a direct effect on energy production was further suggested by later studies on ion movements2,3. It has thus appeared that inhibition of active transport is unaccompanied by a change in energy production in spite of the smaller energy requirements of the cell. Active…
29 Citations
The effects of oligomycin on energy metabolism and cation transport in slices of rat liver. Inhibition of oxidative phosphorylation as the primary action.
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The relationship between the transport of glucose and cations across cell membranes in isolated tissues. I. Stimulation of glycogen deposition and inhibition of lactic acid production in diaphragm, induced by ouabain.
- BiologyBiochimica et biophysica acta
- 1965
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Inhibition by Ouabain of Glycolysis in Ciliary Body
- Biology, ChemistryNature
- 1964
It has been shown that ouabain, a specific inhibitor of sodium–potassium ATPase, causes a 40 per cent decrease in the rate of oxygen uptake in kidney and in liver and a 30% decrease in brain.
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- BiologyBiochimica et biophysica acta
- 1971
Red Cell Glycolysis in the Myo dystrophic Child
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- 1971
The regulation of phosphoglycerate Kinase and pyruvate kinase in vivo followed a normal pattern, and sharp increases of fructose‐1,6‐diphosphate and dihydroxyacetone‐phosphate were observed in the normal cell.
NA-K ACTIVATED ADENOSINETRIPHOSPHATASE AND ACTIVE CATION TRANSPORT IN THE LENS.
- BiologyInvestigative ophthalmology
- 1965
It is concluded that the epithelial Na-K ATPase and the active cation transport system of the lens are identical or very closely related.
Ouabain and the distribution of calcium and magnesium in cerebral tissues in vitro
- BiologyExperimental Brain Research
- 2004
It is clear that in addition to its effects on transport of monovalent cations and on activity of Mg-dependent, Na-K-activated ATPase, ouabain can also affect the distribution of calcium and thereby respiratory metabolism in cerebral cortex.
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