Control of Immunoregulatory Molecules by miRNAs in T Cell Activation

  title={Control of Immunoregulatory Molecules by miRNAs in T Cell Activation},
  author={Ana Rodr{\'i}guez-Gal{\'a}n and Lola Fern{\'a}ndez-Messina and F. S{\'a}nchez-Madrid},
  journal={Frontiers in Immunology},
  • Ana Rodríguez-Galán, Lola Fernández-Messina, F. Sánchez-Madrid
  • Published 2018
  • Biology, Medicine
  • Frontiers in Immunology
  • MiRNA targeting of key immunoregulatory molecules fine-tunes the immune response. This mechanism boosts or dampens immune functions to preserve homeostasis while supporting the full development of effector functions. MiRNA expression changes during T cell activation, highlighting that their function is constrained by a specific spatiotemporal frame related to the signals that induce T cell-based effector functions. Here, we update the state of the art regarding the miRNAs that are… CONTINUE READING
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