Control of Immunoregulatory Molecules by miRNAs in T Cell Activation

@article{RodrguezGaln2018ControlOI,
  title={Control of Immunoregulatory Molecules by miRNAs in T Cell Activation},
  author={Ana Rodr{\'i}guez-Gal{\'a}n and Lola Fern{\'a}ndez-Messina and F. S{\'a}nchez-Madrid},
  journal={Frontiers in Immunology},
  year={2018},
  volume={9}
}
  • Ana Rodríguez-Galán, Lola Fernández-Messina, F. Sánchez-Madrid
  • Published 2018
  • Biology, Medicine
  • Frontiers in Immunology
  • MiRNA targeting of key immunoregulatory molecules fine-tunes the immune response. This mechanism boosts or dampens immune functions to preserve homeostasis while supporting the full development of effector functions. MiRNA expression changes during T cell activation, highlighting that their function is constrained by a specific spatiotemporal frame related to the signals that induce T cell-based effector functions. Here, we update the state of the art regarding the miRNAs that are… CONTINUE READING
    15 Citations

    Figures and Topics from this paper.

    Metabolism and Autoimmune Responses: The microRNA Connection
    • 10
    • PDF
    miRNA-Mediated Immune Regulation in Islet Autoimmunity and Type 1 Diabetes
    The role of T cell miRNAs for regulatory T cell induction in islet autoimmunity
    • 1
    Clinical significance of miRNAs in autoimmunity.
    • 5
    Role of Host and Pathogen-Derived MicroRNAs in Immune Regulation During Infectious and Inflammatory Diseases
    • 4
    • Highly Influenced
    • PDF
    MicroRNAs in Tumor Exosomes Drive Immune Escape in Melanoma
    • 14
    Quantitative and time-resolved miRNA pattern of early human T cell activation
    Anti-tumor and immune modulating activity of T cell induced tumor-targeting effectors (TITE)

    References

    SHOWING 1-10 OF 133 REFERENCES
    MicroRNA regulation of T‐cell differentiation and function
    • 101
    • PDF
    Mechanism of T cell regulation by microRNAs
    • 44
    miRNA profiling during antigen-dependent T cell activation: A role for miR-132-3p
    • 11
    A role for Dicer in immune regulation
    • 513
    • PDF
    MicroRNA-mediated regulation of T helper cell differentiation and plasticity
    • 263
    Costimulation-Dependent Expression of MicroRNA-214 Increases the Ability of T Cells To Proliferate by Targeting Pten
    • 91
    • PDF
    MiR-568 inhibits the activation and function of CD4⁺ T cells and Treg cells by targeting NFAT5.
    • 39
    • Highly Influential
    • PDF
    TGF-β: A Master of All T Cell Trades
    • 638
    mTOR Signaling in T Cell Immunity and Autoimmunity
    • 38