Control of Haemoglobin Synthesis: a Difference in the Size of the Polysomes making α and β Chains
@article{Hunt1968ControlOH, title={Control of Haemoglobin Synthesis: a Difference in the Size of the Polysomes making $\alpha$ and $\beta$ Chains}, author={R. T. Hunt and Anthony Hunter and Alan J. Munro}, journal={Nature}, year={1968}, volume={220}, pages={481-483} }
HAEMOGLOBIN is composed of equimolar amounts of α and β chains. Although it is not essential to synthesize the same number of molecules of each chain, this was originally thought to be the case1. The finding of a pool of α chains in rabbit reticulocytes implies that either at some stage there has been excess synthesis of α chains, or that the α chains are continually produced in excess of β chains2–4. An understanding of the mechanisms which control the balance of the synthesis of the two…
53 Citations
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