Control of HL-60 monocytic differentiation. Different pathways and uncoupled expression of differentiation markers.

@article{Yen1987ControlOH,
  title={Control of HL-60 monocytic differentiation. Different pathways and uncoupled expression of differentiation markers.},
  author={Andrew Ying-Ming Yen and Dennis L. Brown and J K Fishbaugh},
  journal={Experimental cell research},
  year={1987},
  volume={168 1},
  pages={247-54}
}
Control of expression of the terminally differentiated phenotype was studied using the human promyelocytic leukemia cell line HL-60. Three known inducers of HL-60 monocytic differentiation were compared: 1,25-dihydroxy vitamin D3, tetradecanoylphorbol acetate (TPA), and sodium butyrate. At concentrations where all three inducers resulted in similar courses of G1/0-specific growth arrest, the kinetics of appearance of certain differentiation markers typically characteristic of mature monocytic… CONTINUE READING