Control of Glycinergic Input to Spinal Dorsal Horn Neurons by Distinct Muscarinic Receptor Subtypes Revealed Using Knockout Mice

@article{Zhang2007ControlOG,
  title={Control of Glycinergic Input to Spinal Dorsal Horn Neurons by Distinct Muscarinic Receptor Subtypes Revealed Using Knockout Mice},
  author={Hong-Mei Zhang and Hong-yi Zhou and Shao‐Rui Chen and Dinesh Chandra Gautam and J{\"u}rgen Wess and Hui-Lin Pan},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  year={2007},
  volume={323},
  pages={963 - 971}
}
Muscarinic acetylcholine receptors (mAChRs) play an important role in the tonic regulation of nociceptive transmission in the spinal cord. However, how mAChR subtypes contribute to the regulation of synaptic glycine release is unknown. To determine their role, glycinergic spontaneous inhibitory postsynaptic currents (sIPSCs) were recorded in lamina II neurons by using whole-cell recordings in spinal cord slices of wild-type (WT) and mAChR subtype knockout (KO) mice. In WT mice, the mAChR… 
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References

SHOWING 1-10 OF 51 REFERENCES
Opposing Functions of Spinal M2, M3, and M4 Receptor Subtypes in Regulation of GABAergic Inputs to Dorsal Horn Neurons Revealed by Muscarinic Receptor Knockout Mice
TLDR
Data strongly suggest that activation of the M3 subtype increases synaptic GABA release in the spinal dorsal horn of mice, an action that is opposite to the role of M2 and M4 subtypes inThe spinal cord of rats.
Dynamic regulation of glycinergic input to spinal dorsal horn neurones by muscarinic receptor subtypes in rats
TLDR
Data suggest that the M3 subtype is present on the somatodendritic site of glycinergic neurones and is mainly responsible for muscarinic potentiation of Glycinergic input to spinal dorsal horn neurones.
M2, M3, and M4 Receptor Subtypes Contribute to Muscarinic Potentiation of GABAergic Inputs to Spinal Dorsal Horn Neurons
TLDR
It is suggested that M2 and M4 receptor subtypes play a predominant role in muscarinic potentiation of synaptic GABA release in the spinal cord and the M3 subtype also contributes to increased GABAergic tone in spinal dorsal horn by mus carinic agonists.
M 2 , M 3 , and M 4 Receptor Subtypes Contribute to Muscarinic Potentiation of GABAergic Inputs to Spinal Dorsal Horn Neurons
TLDR
To determine the role of receptor subtypes in the muscarinic agonist-induced synaptic GABA release in the spinal cord, spontaneous inhibitory postsynaptic currents (sIPSCs) were recorded in lamina II neurons using whole-cell voltage-clamp recordings in rat spinal cord slices and suggest M2 and M4 receptor sub types play a predominant role.
Role of Presynaptic Muscarinic and GABAB Receptors in Spinal Glutamate Release and Cholinergic Analgesia in Rats
TLDR
Data from this integrated study provide new information that acetylcholine inhibits the glutamatergic synaptic input to lamina II neurons through presynaptic muscarinic receptors.
Functional Activity of the M2 and M4 Receptor Subtypes in the Spinal Cord Studied with Muscarinic Acetylcholine Receptor Knockout Mice
TLDR
This study provides complementary new evidence that M2 is the most predominant mAChR subtype coupled to the Gi/o proteins in the spinal cord and suggests that a small but functionally significant population of M4 receptors exists in the mouse spinal cord.
Activation of muscarinic receptors inhibits spinal dorsal horn projection neurons: role of GABAB receptors
Muscarinic Acetylcholine Receptor Knockout Mice
TLDR
Behavioral and neurochemical studies showed that M5 receptor activity modulates both morphine reward and withdrawal processes, probably through activation of M5 receptors located on midbrain dopaminergic neurons.
Two distinct classes of muscarinic action on hippocampal inhibitory synapses: M2‐mediated direct suppression and M1/M3‐mediated indirect suppression through endocannabinoid signalling
TLDR
The muscarinic system can influence hippocampal functions by controlling different subsets of inhibitory synapses through the two distinct mechanisms, namely a cannabinoid‐dependent and cannabinoid‐independent mechanism.
Enhancement of D1 dopamine receptor-mediated locomotor stimulation in M(4) muscarinic acetylcholine receptor knockout mice.
  • J. Gomeza, L. Zhang, +7 authors J. Wess
  • Biology, Psychology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1999
TLDR
Results indicate that M(4) receptors exert inhibitory control on D1 receptor-mediated locomotor stimulation, probably at the level of striatal projection neurons where the two receptors are coexpressed at high levels.
...
1
2
3
4
5
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