Control of Germline Stem Cell Division Frequency – A Novel, Developmentally Regulated Role for Epidermal Growth Factor Signaling

@inproceedings{Parrott2012ControlOG,
  title={Control of Germline Stem Cell Division Frequency – A Novel, Developmentally Regulated Role for Epidermal Growth Factor Signaling},
  author={Benjamin B. Parrott and Alicia G. Hudson and Regina Brady and Cordula Schulz},
  booktitle={PloS one},
  year={2012}
}
Exploring adult stem cell dynamics in normal and disease states is crucial to both better understanding their in vivo role and better realizing their therapeutic potential. Here we address the division frequency of Germline Stem Cells (GSCs) in testes of Drosophila melanogaster. We show that GSC division frequency is under genetic control of the highly conserved Epidermal Growth Factor (EGF) signaling pathway. When EGF signaling was attenuated, we detected a two-fold increase in the percentage… CONTINUE READING
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