Control of Escherichia coli isocitrate dehydrogenase: an example of protein phosphorylation in a prokaryote

@inproceedings{Nimmo1984ControlOE,
  title={Control of Escherichia coli isocitrate dehydrogenase: an example of protein phosphorylation in a prokaryote},
  author={Hugh G Nimmo},
  year={1984}
}
In micro-organisms growing on acetate, isocitrate can be metabolized either by the tricarboxylic acid cycle or by the glyoxylate bypass. In Escherichia coli this branch-point is controlled by reversible phosphorylation and inactivation of isocitrate dehydrogenase. Both phosphorylation and dephosphorylation are catalysed by a single bifunctional kinase/phosphatase. The properties of this enzyme suggest that phosphorylation of isocitrate dehydrogenase is controlled by the concentrations of… CONTINUE READING