Control of Effector CD8+ T Cell Function by the Transcription Factor Eomesodermin

@article{Pearce2003ControlOE,
  title={Control of Effector CD8+ T Cell Function by the Transcription Factor Eomesodermin},
  author={Erika L. Pearce and Alan C. Mullen and Gisl{\^a}ine A Martins and Connie M. Krawczyk and Anne S. Hutchins and Valerie P. Zediak and Monica Banica and Catherine B. DiCioccio and Darrick A Gross and Chai-An Mao and Hao Shen and Nezih Cereb and Soo Young Yang and Tullia Lindsten and Janet Rossant and Christopher A. Hunter and Steven L. Reiner},
  journal={Science},
  year={2003},
  volume={302},
  pages={1041 - 1043}
}
Activated CD8+ T cells play a critical role in host defense against viruses, intracellular microbes, and tumors. It is not clear if a key regulatory transcription factor unites the effector functions of CD8+ T cells. We now show that Eomesodermin (Eomes), a paralogue of T-bet, is induced in effector CD8+ T cells in vitro and in vivo. Ectopic expression of Eomes was sufficient to invoke attributes of effector CD8+ T cells, including interferon-γ (IFN-γ), perforin, and granzyme B. Loss-of… 
CD152 (CTLA‐4) regulates effector functions of CD8+ T lymphocytes by repressing Eomesodermin
TLDR
It is demonstrated that signals induced by CD152 reduce the frequency of IFN‐γ and granzyme B expressing CD8+ T cells independently of the transcription factors T‐bet or cKrox by selectively inhibiting accumulation of Eomesodermin mRNA and protein.
Notch Regulates Cytolytic Effector Function in CD8+ T Cells1
TLDR
It is concluded that Notch activity mediates CTL activity through direct regulation of EOMES, perforin, and granzyme B through direct binding to the promoters of these crucial effector molecules.
Type I interferons regulate eomesodermin expression and the development of unconventional memory CD8+ T cells
TLDR
It is demonstrated that type I interferon signalling in CD8+ T cells drives Eomes expression and thereby regulates the function and homeostasis of memory-like CD8-cell memory cells.
Cutting Edge: The Transcription Factor Eomesodermin Enables CD8+ T Cells To Compete for the Memory Cell Niche
TLDR
The phenotype of Eomes-deficient CD8+ T cells supports the hypothesis that T-bet and Eomes can act redundantly to induce effector functions, but can also act to reciprocally promote terminal differentiation versus self-renewal of Ag-specific memory cells.
The role of Ikaros in CD8+ T cell biology
TLDR
It is demonstrated that naà ̄ve CD8+ T cells with only one copy of Ikaros can differentiate in vitro into cytolytic effectors with enhanced effector function, and this results from increased autocrine IL-2 production.
Eomes cannot replace its paralog T-bet during expansion and differentiation of CD8 effector T cells
TLDR
The results clearly underline the importance of T-bet in guiding canonical CTL development during acute viral infections and show that imposed expression of Eomes after acute viral infection promotes some features of exhaustion but must act in concert with other factors during chronic viral infection to establish all hallmarks of exhaustion.
The Role Of miRNAs In CD8+ T Cell Differentation
TLDR
A transcriptome-wide analysis of miRNA expression in YFP versus YFP CD8 thymocytes from an Ifng-YFP reporter mouse suggested that miR-132 is a possible negative regulator of IFN-γ expression in CD8 T cells.
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