Control of DNA replication by cyclin-dependent kinases in development.

  title={Control of DNA replication by cyclin-dependent kinases in development.},
  author={Daniel Fisher},
  journal={Results and problems in cell differentiation},
Cyclin-dependent kinases (CDKs) are required for initiation of DNA replication in all eukaryotes, and appear to act at multiple levels to control replication origin firing, depending on the cell type and stage of development. In early development of many animals, both invertebrate and vertebrate, rapid cell cycling is coupled with transcriptional repression, and replication initiates at closely spaced replication origins with little or no sequence specificity. This organisation of DNA… CONTINUE READING


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Cdk2 functions in the cell cycle. Cell cycle

  • A Kumagai, A Shevchenko, WG Dunphy
  • 2010
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