Control of Centrin Stability by Aurora A

@inproceedings{Lukasiewicz2011ControlOC,
  title={Control of Centrin Stability by Aurora A},
  author={Kara B. Lukasiewicz and Tammy M. Greenwood and Vivian C. Negron and Amy K. Bruzek and Jeffrey L. Salisbury and Wilma L. Lingle},
  booktitle={PloS one},
  year={2011}
}
Aurora A is an oncogenic serine/threonine kinase which can cause cell transformation and centrosome amplification when over-expressed. Human breast tumors show excess Aurora A and phospho-centrin in amplified centrosomes. Here, we show that Aurora A mediates the phosphorylation of and localizes with centrin at the centrosome, with both proteins reaching maximum abundance from prophase through metaphase, followed by their precipitous loss in late stages of mitosis. Over-expression of Aurora A… CONTINUE READING

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Here , we show that Aurora A mediates the phosphorylation of and localizes with centrin at the centrosome , with both proteins reaching maximum abundance from prophase through metaphase , followed by their precipitous loss in late stages of mitosis .
Here , we show that Aurora A mediates the phosphorylation of and localizes with centrin at the centrosome , with both proteins reaching maximum abundance from prophase through metaphase , followed by their precipitous loss in late stages of mitosis .
Here , we show that Aurora A mediates the phosphorylation of and localizes with centrin at the centrosome , with both proteins reaching maximum abundance from prophase through metaphase , followed by their precipitous loss in late stages of mitosis .
Control of Centrin Stability by Aurora A. Aurora A is an oncogenic serine / threonine kinase which can cause cell transformation and centrosome amplification when over - expressed .
Here , we show that Aurora A mediates the phosphorylation of and localizes with centrin at the centrosome , with both proteins reaching maximum abundance from prophase through metaphase , followed by their precipitous loss in late stages of mitosis .
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