Control of B lymphocyte apoptosis by the transcription factor NF-kappaB.

  title={Control of B lymphocyte apoptosis by the transcription factor NF-kappaB.},
  author={Ranjan Sen},
  volume={25 6},
B cells maintain homeostasis by balancing cell viability and cell death. B lymphocytes are susceptible to mitochondria- and receptor-initiated cell death at various stages of peripheral differentiation and during immune responses. The inducible transcription factor NF-kappaB enhances cell viability by activating genes that counteract both cell-death pathways. This review uses characteristic features of NF-kappaB activation and downregulation to provide insight into the regulation of B cell… CONTINUE READING

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