Control of B cell development by the histone H2A deubiquitinase MYSM1.

  title={Control of B cell development by the histone H2A deubiquitinase MYSM1.},
  author={Xiao-xia Jiang and Quan Nguyen and Yuchia Chou and Tao Wang and Vijayalakshmi Nandakumar and Peter Yates and Lindsey E Jones and Lifeng Wang and Haejung Won and Hye-Ra Lee and Jae U Jung and Markus M{\"u}schen and Xue Feng Huang and Si-Yi Chen},
  volume={35 6},
Epigenetic histone modifications play critical roles in the control of gene transcription. Recently, an increasing number of histone H2A deubiquitinases have been identified and characterized. However, the physiological functions for this entire group of histone H2A deubiquitinases remain unknown. In this study, we revealed that the histone H2A deubiquitinase MYSM1 plays an essential and intrinsic role in early B cell development. MYSM1 deficiency results in a block in early B cell commitment… CONTINUE READING
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