Control of Antibiotic-Resistant Bacteria in Activated Sludge Using Polyvalent Phages in Conjunction with a Production Host

@inproceedings{Yu2017ControlOA,
  title={Control of Antibiotic-Resistant Bacteria in Activated Sludge Using Polyvalent Phages in Conjunction with a Production Host},
  author={Pingfeng Yu and Jacques R. R. Mathieu and Grant W. Lu and Naiana Gabiatti and Pedro J J Alvarez},
  year={2017}
}
Bacteriophage-based microbial control could help address a growing need to attenuate the proliferation of antibiotic-resistant bacteria (ARB) in wastewater treatment plants (WWTPs). However, the infectivity of commonly isolated narrow-host-range phages decreases quickly upon addition to activated sludge (i.e., plaque-forming units had a half-life of 0.63 h). Here, we show that polyvalent (broad-hostrange) phages proliferate and thrive in activated sludge microcosms, especially when added along… CONTINUE READING

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