Control of AIF-mediated cell death by antagonistic functions of CHIP ubiquitin E3 ligase and USP2 deubiquitinating enzyme

@article{Oh2011ControlOA,
  title={Control of AIF-mediated cell death by antagonistic functions of CHIP ubiquitin E3 ligase and USP2 deubiquitinating enzyme},
  author={Kyu Hee Oh and Seung Wook Yang and Jun Myoung Park and Jae Hong Seol and Shun-ichiro Iemura and Toru Natsume and Shigeo Murata and Kohichi Tanaka and Yun jae Jeon and Christine H. Chung},
  journal={Cell Death and Differentiation},
  year={2011},
  volume={18},
  pages={1326-1336}
}
Apoptosis inducing factor (AIF) is a mitochondrial oxidoreductase that scavenges reactive oxygen species under normal conditions. Under certain stresses, such as exposure to N-methyl-N′-nitro-N′-nitrosoguanidine (MNNG), AIF is truncated and released from the mitochondria and translocated into the nucleus, where the truncated AIF (tAIF) induces caspase… CONTINUE READING