Control of 5′,5′-Dinucleoside Triphosphate Catabolism by APH1, a Saccharomyces cerevisiaeAnalog of Human FHIT

@article{Chen1998ControlO5,
  title={Control of 5′,5′-Dinucleoside Triphosphate Catabolism by APH1, a Saccharomyces cerevisiaeAnalog of Human FHIT},
  author={Josiane Chen and A. Brevet and S. Blanquet and P. Plateau},
  journal={Journal of Bacteriology},
  year={1998},
  volume={180},
  pages={2345 - 2349}
}
ABSTRACT The putative human tumor suppressor gene FHIT (fragile histidine triad) (M. Ohta et al., Cell 84:587–597, 1996) encodes a protein behaving in vitro as a dinucleoside 5′,5′′′-P1,P3-triphosphate (Ap3A) hydrolase. In this report, we show that the Saccharomyces cerevisiae APH1 gene product, which resembles human Fhit protein, also hydrolyzes dinucleoside 5′,5′-polyphosphates, with Ap3A being the preferred substrate. Accordingly, disruption of the APH1 gene produced viable S… Expand
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TLDR
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