Control of β-Cell Differentiation by the Pancreatic Mesenchyme

  title={Control of β-Cell Differentiation by the Pancreatic Mesenchyme},
  author={Myriam Attali and Volodymyr Stetsyuk and Annie Basmaciogullari and Virginie Aiello and Maria Antonietta Zanta-Boussif and Bertrand Duvilli{\'e} and Rapha{\'e}l Scharfmann},
The importance of mesenchymal-epithelial interactions for normal development of the pancreas was recognized in the early 1960s, and mesenchymal signals have been shown to control the proliferation of early pancreatic progenitor cells. The mechanisms by which the mesenchyme coordinates cell proliferation and differentiation to produce the normal number of differentiated pancreatic cells are not fully understood. Here, we demonstrate that the mesenchyme positively controls the final number of… CONTINUE READING