Control mechanism of JAK/STAT signal transduction pathway

@article{Yamada2003ControlMO,
  title={Control mechanism of JAK/STAT signal transduction pathway},
  author={Satoshi Yamada and Satoru Shiono and Akiko Joo and Akihiko Yoshimura},
  journal={FEBS Letters},
  year={2003},
  volume={534}
}

Computational and mathematical models of the JAK-STAT signal transduction pathway

A deterministic mathematical model is implemented using the ODEs solver CO-PASI, and a stochastic computational model is built using the Stochastic Pi Machine (SPiM) that has the potential to contribute to cancer research.

Effect of SHP-2, SOCS3, and PP2 on IL-6 signal transduction in hepatocytes

A mathematical model has been developed that integrates signaling through both JAK/STAT and MAPK pathways and it is shown that SHP-2 and SOCS3 do not just influence the pathway that they are mainly associated with, but also have a profound effect on the other pathway due to interactions of the pathways.

Mathematical Model of IL-6 signal transduction in Hepatocytes

It can be determined that the influence of SOCS3 and SHP-2 on signaling induced by IL-6 is not independent of each other and the developed model used to analyze the interactions between the two pathways is found to predict behavior inline with the experimental studies.

Systems biology of JAK/STAT signalling.

A data-based model of the core module of the JAK2/STAT5 signalling pathway showed that rapid nucleocytoplasmic cycling of STAT5 is an essential pathway property.

Modeling regulatory mechanisms in IL‐6 signal transduction in hepatocytes

A mathematical model has been developed that integrates signaling through both the JAK/STAT and the MAPK pathway and suggests that interactions between SHP‐2 and SOCS3 influence signaling through theJAK/ STAT and theMAPK pathways.

Robustness Analysis of the IFN-γ Induced JAK-STAT Signaling Pathway

The study demonstrates that the JAK-STAT signaling pathway is robust with respect to its “signal time” and “Signal duration”, but sensitive with respectto its ”signal amplitude”.

Model-driven experimental analysis of the function of SHP-2 in IL-6-induced Jak/STAT signaling.

An identifiable model of early Jak/STAT signaling is proposed that describes the data and proves to be predictive and implies that the stepwise association of IL-6 with gp80 and gp130 and STAT3 dimerization at the receptor are essential for the dynamics of early pathway activation.
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