Control by the endogenous cannabinoid system of ras oncogene-dependent tumor growth.

@article{Bifulco2001ControlBT,
  title={Control by the endogenous cannabinoid system of ras oncogene-dependent tumor growth.},
  author={Maurizio Bifulco and Chiara Laezza and Giuseppe Portella and Marco Vitale and Pierangelo Orlando and Luciano De Petrocellis and Vincenzo Di Marzo},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2001},
  volume={15 14},
  pages={2745-7}
}
We investigated the effect of 2-methyl-arachidonyl-2'-fluoro-ethylamide (Met-F-AEA), a stable analog of the endocannabinoid anandamide, on a rat thyroid epithelial cell line (FRTL-5) transformed by the K-ras oncogene, and on epithelial tumors derived from these cells. Met-F-AEA effect in vivo was evaluated in a nude mouse xenograft model, where K-ras-transformed (KiMol) cells were implanted subcutaneously. Met-F-AEA (0.5 mg/kg/dose) induced a drastic reduction in tumor volume. This effect was… CONTINUE READING