Control by IFN-gamma and PGE2 of TNF alpha and IL-1 production by human monocytes.

@article{Hart1989ControlBI,
  title={Control by IFN-gamma and PGE2 of TNF alpha and IL-1 production by human monocytes.},
  author={Prue H Hart and Genevieve A Whitty and Diana S. Piccoli and John A Hamilton},
  journal={Immunology},
  year={1989},
  volume={66 3},
  pages={
          376-83
        }
}
There have been suggestions that the production of pro-inflammatory mediators by human monocytes in response to interferon-gamma (IFN-gamma) may be controlled by changes in prostaglandins. Therefore we investigated tumour necrosis factor alpha (TNF alpha) and interleukin-1 (IL-1) activities and prostaglandin E2 (PGE2) levels in the supernatants of highly purified human monocytes cultured for 18 hr with recombinant human IFN-gamma. IFN-gamma (100 U/ml) did not stimulate monocytes isolated by… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 32 CITATIONS

Interferon gamma inhibits interleukin 10 production by monocytes

  • The Journal of experimental medicine
  • 1993
VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED