Contributions of ubiquitin- and PCNA-binding domains to the activity of Polymerase η in Saccharomyces cerevisiae

@inproceedings{Parker2007ContributionsOU,
  title={Contributions of ubiquitin- and PCNA-binding domains to the activity of Polymerase η in Saccharomyces cerevisiae},
  author={Joanne L. Parker and Aleksandra B. Bielen and Ivan Dikic and Helle D Ulrich},
  booktitle={Nucleic acids research},
  year={2007}
}
Bypassing of DNA lesions by damage-tolerant DNA polymerases depends on the interaction of these enzymes with the monoubiquitylated form of the replicative clamp protein, PCNA. We have analyzed the contributions of ubiquitin and PCNA binding to damage bypass and damage-induced mutagenesis in Polymerase η (encoded by RAD30 ) from the budding yeast Saccharomyces cerevisiae . We report here that a ubiquitin-binding domain provides enhanced affinity for the ubiquitylated form of PCNA and is… CONTINUE READING
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