Contributions of the orbitofrontal cortex to impulsive choice: interactions with basal levels of impulsivity, dopamine signalling, and reward-related cues

@article{Zeeb2010ContributionsOT,
  title={Contributions of the orbitofrontal cortex to impulsive choice: interactions with basal levels of impulsivity, dopamine signalling, and reward-related cues},
  author={Fiona D. Zeeb and Stan B Floresco and Catharine A. Winstanley},
  journal={Psychopharmacology},
  year={2010},
  volume={211},
  pages={87-98}
}
Individual differences in impulsive decision-making may be critical determinants of vulnerability to impulse control disorders and substance abuse, yet little is known of their biological or behavioural basis. The orbitofrontal cortex (OFC) has been heavily implicated in the regulation of impulsive decision-making. However, lesions of the OFC in rats have both increased and decreased impulsivity in delay-discounting paradigms, where impulsive choice is defined as the selection of small… CONTINUE READING
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