Contributions of the measles virus nucleocapsid gene and the SQSTM1/p62(P392L) mutation to Paget's disease.

@article{Kurihara2011ContributionsOT,
  title={Contributions of the measles virus nucleocapsid gene and the SQSTM1/p62(P392L) mutation to Paget's disease.},
  author={Noriyoshi Kurihara and Yuko Hiruma and Kei Yamana and La{\"e}titia Michou and C{\^o}me Rousseau and Jean Morissette and Deborah L Galson and Jumpei Teramachi and Hua Zhou and David W. Dempster and Jolene J. Windle and Jacques P Brown and Garson David Roodman},
  journal={Cell metabolism},
  year={2011},
  volume={13 1},
  pages={23-34}
}
Paget's disease (PD) is characterized by abnormal osteoclasts (OCL) that secrete high IL-6 levels and induce exuberant bone formation. Because measles virus nucleocapsid gene (MVNP) and the p62(P392L) mutation are implicated in PD, marrows from 12 PD patients harboring p62(P392L) and eight normals were tested for MVNP expression and pagetic OCL formation. Eight out of twelve patients expressed MVNP and formed pagetic OCL in vitro, which were inhibited by antisense-MVNP. Four out of twelve… CONTINUE READING