Contributions of the individual domains in human La protein to its RNA 3'-end binding activity.

@article{Ohndorf2001ContributionsOT,
  title={Contributions of the individual domains in human La protein to its RNA 3'-end binding activity.},
  author={U M Ohndorf and Clemens Steegborn and Rainer Knijff and Peter Sondermann},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 29},
  pages={27188-96}
}
The autoantigen La regulates the maturation of RNA polymerase III transcripts by binding to their poly(U) termination signal. The modular protein harbors a N-terminal RNA recognition motif (RRM), RRM1, and in the C-terminal domain, a second, atypical RRM2, in addition to a phosphorylation site, and a putative nucleotide binding site. This study presents a… CONTINUE READING