Contributions of sustained INa and IKv43 to transmural heterogeneity of early repolarization and arrhythmogenesis in canine left ventricular myocytes.

@article{Flaim2006ContributionsOS,
  title={Contributions of sustained INa and IKv43 to transmural heterogeneity of early repolarization and arrhythmogenesis in canine left ventricular myocytes.},
  author={Sarah N. Flaim and Wayne R Giles and Andrew D. McCulloch},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2006},
  volume={291 6},
  pages={
          H2617-29
        }
}
The roles of sustained components of I(Na) and I(Kv43) in shaping the action potentials (AP) of myocytes isolated from the canine left ventricle (LV) have not been studied in detail. Here we investigate the hypothesis that these two currents can contribute substantially to heterogeneity of early repolarization and arrhythmic risk. Quantitative data from voltage-clamp and expression profiling experiments were used to complete meaningful modifications to an existing "local control" model of… CONTINUE READING

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